Under GHS, pictograms must be in the shape of a square set at a point with a black hazard symbol, placed on a _______ background with a _______ frame.

The correct answer highlights that under the Globally Harmonized System of Classification and Labelling of Chemicals (GHS), pictograms are specifically designed to communicate hazards effectively. These pictograms must be in a square shape, rotated at a point (diamond shape) with a black hazard symbol. The requirement for a white background allows for high visibility and ensures that the symbol stands out clearly, making it easier for individuals to identify the potential hazards associated with the chemical.

The use of a red frame around the pictogram serves both to outline the hazard and to attract attention. This red border effectively encapsulates the information presented within the pictogram, enhancing its prominence and allowing for immediate recognition of the associated danger.

The other choices do not align with the specific requirements set forth by the GHS for pictograms, thus making them unsuitable for correctly conveying the necessary safety information in a standardized manner. The emphasis on clarity and recognizability in hazard communication is the key reason why the correct answer is essential in ensuring safety compliance in various environments where chemicals are handled.